Sunday, August 4, 2013

Tea party plans to abandon GOP stars

MIAMI (AP) ? This wasn't the revolution the tea party had in mind.

Four years ago, the movement and its potent mix of anger and populism persuaded thousands of costumed and sign-waving conservatives to protest the ballooning deficit and President Obama's health care law. It swept a crop of no-compromise lawmakers into Congress and governor's offices and transformed political up-and-comers, including Florida Sen. Marco Rubio, into household names.

But as many tea party stars seek re-election next year and Rubio considers a 2016 presidential run, conservative activists are finding themselves at a crossroads. Many of their standard-bearers have embraced more moderate positions on bedrock issues such as immigration and health care, broadening their appeal in swing states but dampening grass-roots passion.

"They keep sticking their finger in the eyes of the guys who got them elected," said Ralph King, a co-founder of the Cleveland Tea Party Patriots. "A lot of people are feeling betrayed."

The tea party is a loosely knit web of activists, and some are hoping to rekindle the fire with 2014 primary challenges to wayward Republicans. But many more say they plan to sit out high-profile races in some important swing states next year, a move that GOP leaders fear could imperil the re-election prospects of former tea party luminaries, including the governors of Florida and Ohio.

"It changes the playing field for us," said Tom Gaitens, former Florida director of FreedomWorks, a political action committee that has spent millions of dollars to help tea party candidates. "The most powerful thing we have as a movement is our feet and our vote."

In the summer of 2009, tea party supporters stormed congressional town hall meetings, shouting down lawmakers who had voted for the bank bailout and the stimulus package. The movement's voice grew louder after Democrats passed the health care overhaul, and voters took their outrage to the polls in 2010. The tea party wave stunned Democrats and many moderate Republicans, sweeping the GOP into control of the House and changing the balance of power in many statehouses.

But not long after some tea party stars took office, political analysts said, they were forced to adapt to a changing landscape, particularly in states Obama won in 2012, and to the realities of governing.

The tea party also fell out of favor with many people. At its height after the 2010 elections, a CBS News poll found that 31 percent of those surveyed considered themselves tea party supporters. A May survey found just 24 percent identified with the movement.

Facing sagging approval ratings, tea party Republicans, some of whom were elected by slim margins, shifted tactics.

Fla. Gov. Rick Scott, a former health care company executive who won office by attacking the health law and calling for deep cuts to state spending, has embraced the health law and signed one of the largest budgets in state history, complete with pay raises for teachers. Similarly, Gov. John Kasich, R-Ohio, and Rick Snyder, R-Mich., are battling their GOP-dominated legislatures to expand Medicaid, a big part of the health law.

Tea party supporters were most struck by Rubio, the son of Cuban immigrants. His personal story and unlikely rise to power made him perhaps the most prominent figure in the movement.

As a Senate candidate in 2010, he denounced as "amnesty" any plan that would offer a path to citizenship for those who were in the country illegally. Yet in recent months, he has emerged as a leader of a bipartisan Senate group that developed a plan that includes such a provision. The plan has been panned by conservatives but ultimately could bolster Rubio's standing with Hispanics, a growing demographic group that has voted overwhelmingly Democratic in recent years.

One sweltering July day, a half-dozen tea party protesters gathered under a tree in front of Rubio's Miami office, seeking shade as they denounced his support for an immigration overhaul. But the protest soon turned into more of a support group, with the four men and two women grousing to each other about how Rubio had turned into a "back-stabber," a "liar" and a "flip-flopper."

Juan Fiol, a real estate broker who organized the protest, kept looking at his phone, waiting for calls from fellow tea party supporters that never came.

"It was supposed to be a big event," he said as he waved a large "Don't Tread on Me" flag.

The movement's top strategists acknowledge the tea party is quieter today, by design. It has matured, they said, from a protest movement to a political movement. Large-scale rallies have given way to strategic letter-writing and phone-banking campaigns to push or oppose legislative agendas in Washington and state capitals. In Michigan and Ohio, for example, leaders have battled the implementation of the president's health law and the adoption of "Common Core" state school standards.

Local activists say they have focused largely on their own communities since Obama's re-election and the ideological drift of some tea party-backed politicians. Many are running for school boards, county commissions and city councils, focusing on issues such as unfunded pension liabilities and sewer system repairs.

"The positions that people are filling at the local levels are more important for the future of the movement and the future of the country," said Jenny Beth Martin, co-founder of the Tea Party Patriots, a national umbrella organization. "It's creating a farm team for the future."

The Republican establishment, however, is concerned about 2014. Party leaders worry about the GOP's most passionate advocates walking away, particularly those supporters angered by the Senate's immigration bill. In a nod to the tea party, business and conservative groups have launched ad campaigns recasting the bill as a national security measure.

The conservative American Action Network spent $750,000 on pro-reform commercials. One ad aimed at Florida voters called the legislation "the toughest border security plan ever passed by Congress" and urged viewers to thank Rubio for "keeping his promise and fighting to secure the border."

National tea party leaders hope to re-energize followers by focusing on two of the movement's chief targets: the Internal Revenue Service and the health law. They said the Obama administration had handed them a recruiting tool when it delayed the law's implementation and when the IRS singled out tea party groups and other conservative political organizations for special scrutiny.

"The very issues that brought us together in the first place are emerging as more center stage than they were in 2009 and 2010," said Matt Kibbe, president of FreedomWorks. "That animates the political conversation and mobilizes our grass roots going into the 2014 election."

Some Republicans are also moving to repair their relationships with the movement.

Rubio recently spoke to about 50 conservative activists and other lawmakers at a meeting of the Senate's tea party caucus. Organizers said he breezed past immigration, instead devoting much of his speech to repealing the health law.

___

Follow Michael J. Mishak on Twitter: https://twitter.com/mjmishak

Source: http://news.yahoo.com/tea-party-plans-abandon-gop-stars-083902786.html

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Saturday, April 20, 2013

A surprising new function for small RNAs in evolution

Friday, April 19, 2013

It has long been known that certain proteins, known as transcription factors, directly control the way in which information is read from DNA. As a result, it is widely believed that changes in genes encoding such proteins underlie the mechanisms responsible for evolutionary adaptation. The idea that small RNA molecules, so-called microRNAs, may play an important part in evolutionary changes to animals' appearance is completely new. An international team of researchers, including Christian Schl?tterer and Alistair McGregor from the Institute of Population Genetics of the University of Veterinary Medicine, Vienna (Vetmeduni Vienna), has now published a study that describes such an evolutionary mechanism.

Small and large bald patches

Insect bodies are generally covered with a large number of microscopic hairs. This is the case for the legs of many closely related species of the fruit fly genus Drosophila, although the animals have a bald patch on the second pair of legs, intriguingly known as the naked valley. Previous work had shown that the size of this patch is regulated by the gene ultrabithorax (Ubx) and that it differs between species. However, the work at the Vetmeduni Vienna showed that similar differences are shown by individuals from different populations of Drosophila melanogaster.

Their search for the genetic basis of the variation led the researchers to a segment of fruit fly DNA that contained four genes. Three of these genes were known to encode proteins with no role in the development of the hairs. The fourth gene, known as miR-92a, encodes a microRNA. Previous experiments had shown that an increase in activity of the miR-92a gene was associated with a loss of hairs from the animals' wings. By overexpressing the gene in the legs of the fruit flies, the scientists were able to cause hair loss on the animals' legs.

Schl?tterer is naturally excited by the findings. "This is the first experiment to show that natural variation in the expression of a microRNA can lead to a change in the appearance of an organism. MicroRNAs can fine-tune the level at which genes are expressed, so evolutionary changes in the production of microRNA would be an elegant way to cause morphological changes."

###

University of Veterinary Medicine -- Vienna: http://www.vetmeduni.ac.at

Thanks to University of Veterinary Medicine -- Vienna for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127825/A_surprising_new_function_for_small_RNAs_in_evolution

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Monday, January 28, 2013

Social Security and Medicare: Do you get back what you pay in?

People who pay into Social Security and Medicare their whole working lives are often told by politicians that they've 'earned' these retirement benefits. Here's why that's not necessarily so.

By Peter Grier,?Staff writer / January 25, 2013

This 2005 photo shows rolls of blank social security checks at the U.S. Treasury's Financial Management services facility in Philadelphia.

Bradley C Bower/AP/File

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Are Social Security and Medicare ?earned entitlements,? returning benefits for which recipients have already paid?

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The question arises because earlier this week House Budget Committee Chairman Paul Ryan (R) of Wisconsin said they are. Appearing on Laura Ingraham?s radio show on Jan. 22, Representative Ryan said President Obama had mischaracterized the GOP?s attitude toward the nation?s big social insurance programs.

?No one is suggesting that what we call our earned entitlements ? entitlements you pay for, like payroll taxes for Medicare and Social Security ? are putting you in a ?taker? category,? said Ryan. ?No one would suggest that whatsoever.?

Of course, Ryan is far from the only politician to describe Social Security and Medicare in this manner. The wording may be more common among Democrats, who often imply that these programs are simply keeping folks? tax cash warm until they need it ? so hands off!

Let?s quote Mr. Obama himself from an appearance last September before an American Association of Retired Persons audience: ?I want to emphasize, Medicare and Social Security are not handouts. You?ve paid into these programs your whole lives. You?ve earned them.?

To this we say, weelllll, not really. The situation is more complicated than that.

It?s true that workers fork over Social Security and Medicare taxes every payday. But under current law, over their lifetimes most Americans will get back substantially more from these programs then they?ve paid in, even after accounting for inflation and adjusting for interest you might have earned if you?d kept the money.

That?s primarily due to the rising value of projected Medicare health benefits. Social Security is a different story. In recent years the raising of the Social Security retirement age, plus other tweaks, have made the big retirement income entitlement less generous. New retirees won?t get back quite as much income support as they?ve contributed in Social Security taxes.

However, individual tax/benefit ratios for both programs are highly variable, depending on lifetime earnings, longevity, marital status, and health conditions.

Got all that? We weren?t kidding when we said it was ?complicated.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/yKAEdh-O0Vw/Social-Security-and-Medicare-Do-you-get-back-what-you-pay-in

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Thursday, November 15, 2012

MintLife Blog | Personal Finance News & Advice | Frugal Foodie's ...

holiday wine

The holiday season is a prime time to have a few good bottles of wine on hand.

If you don?t need them for your family gatherings or other events that you?re hosting, bottles of wine make an easy grab-and-go contribution for friends? parties or a last-minute gift.

We?ve talked about plenty of ways to get a good deal on wine: buy in bulk,?for example, and look for half-priced wine vouchers?at daily deal sites.

But price is just part of the equation. ?You also want to get the right wine: one that?s good enough to be noted as such by the people drinking it, while cheap enough to serve an entire table of relatives or party of friends,? says Wesley Narron, chief wine ambassador at CityWineTours.com.

As he puts it, ?Your significant other will be impressed. Your auntie will chug-a-lug. And you?ll have some great wine with the ?meal, a happy wallet, and a much better buzz than Nana?s jug wine.?

We asked Narron and other wine experts for their picks, as well as a few specific bottles that come in under the $20 mark:

Beaujolais Nouveau

This French variety is only available during the holiday season ? it?s the first release of this year?s vintage, explains Bob Wilson, the chief executive of Winestyr.com.

?Any brand will work, as this is simple wine that hasn?t been aged,? he says. Most bottles run $9 to $20.?Try one as a gift, or pair with foods early into a holiday meal before heavier wines make an appearance.

Vouvray

At first glance, Narron says, this little-known, ever-so-slightly-sweet white wine from France looks like ?the type of wine your wine-snob brother-in-law will disdain.?

But a Vouvray made #6 on Decanter Magazine?s list of the 100 Greatest Wines ever made, and its cheaper counterparts are a worthy choice for a holiday meal.

He likes the Domain de Vaufuget Vouvray for $10, the Charles Bove? Vouvray for $14, or the Marc Bredif Vouvray for $20.

Sparkling Cider

Hard cider is having its moment as an ?it? drink. But for a place at a holiday table, look to those that are more like wine than beer.

Arthur Hon, wine director at Chicago restaurant Sepia, likes the 2009 Eric Bordelet Poir? ?Authentique? from Normandy, a pear cider that sells for $19.

?It has slight sweetness that would work better at the end of meals, but with savory dishes that include fruit elements will be an eye-opening pairing,? he says.

Pinot Gris

?If you like a white with your Thanksgiving meal, Pinot Gris pairs well with turkey and all its fixings,? Wilson says.

Compared to a Pinot Grigio, which is made from the same grape, the French-style Pinot Gris is fuller-bodied and has more mineral flavors.

His pick: Rocky Hill 2010 Pinot Gris from Sonoma, which sells for $19.

Cava

?When it comes to sparkling wine, Spanish Cava can be one of the more budget-friendly picks,? says sommelier Matthew Carroll of BRABO restaurant and its shop, the Butcher?s Block, in Alexandria, Va.

He likes Castillo Perelada Brut Cava, a non-vintage sparkler that sells for $12. ?It?s a beautiful dry sparkler that will work just as beautifully with turkey as it will with cranberry sauce, stuffing and sweet potatoes,? Carroll says.

Rioja

Rioja ?has the same strawberry-cherry?aromas of Pinot Noir, and some of the floral characteristics of Chianti, ?minus the smokiness or earthiness,? Narron says.

Prices rise the longer the wine has been barrel-aged. Look for a bottle with ?Crianza? or ?Reserva? in the name. ??Tinto? varieties have little aging and can be too harsh, while a ?Gran Reserva? isn?t enough of a flavor upgrade to justify the cost,? he says.

Two picks: the ?Marques de Caceres Crianza and the Lan Crianza, both $14.

Frugal Foodie is a journalist based in New York City who spends her days writing about personal finance and obsessing about what she?ll have for dinner. Chat with her on Twitter through @MintFoodie.

Source: http://www.mint.com/blog/consumer-iq/frugal-foodies-top-picks-for-holiday-wine-steals-and-deals-1112/

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Hobart squash will compete in 2012 Liberty League

The Hobart College squash team will travel to Poughkeepsie, N.Y., to compete in the 2012 Liberty League Championship hosted by Vassar College this weekend.

The Statesmen, who are ranked No. 25 in the College Squash Association preseason rankings, will start the weekend taking on No. 5 Rochester at 2:30 p.m. on Saturday, Nov. 17.? Hobart will square off with No. 11 St. Lawrence at 4:30 p.m. to round out Day 1. On Sunday, Nov. 18, the Statesmen will take on the Brewers at 9 a.m., and then face Bard at 11 a.m.

Hobart is off to a 2-3 start this season. The Statesmen opened the year with a 9-0 sweep of Ithaca. Hobart then traveled to Annapolis, Md., to take part in the Navy Round Robin. The Statesmen picked up a 5-4 win over No. 29 Georgetown, but dropped matches to No. 13 Navy, No. 28 Johns Hopkins and No. 16 George Washington.

First-years Peter Sammis and Michael Woods lead the Statesmen with three wins each. Sammis has posted a 3-2 record at No. 7, while Woods is 2-2 at No. 8 and 1-0 at No. 9. Sophomore McGee O'Neil has played all five matches at the No. 1 spot, logging a 2-3 record.
?
In 2011, Hobart went 2-2 in the Liberty League Championship. The Statesmen topped Bard 9-0 and defeated Vassar 8-1, but fell to St. Lawrence and Rochester.

Source: http://www.hwsathletics.com/news/2012/11/15/HSQ_1115124430.aspx

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Wednesday, November 14, 2012

Heart failure in older breast cancer patients linked to medication

ScienceDaily (Nov. 14, 2012) ? Heart failure is a relatively common complication in older women with breast cancer, but the risk is even higher in those patients treated with adjuvant trastuzumab (Herceptin?), Yale School of Medicine researchers report in the current issue of the Journal of the American College of Cardiology.

The researchers conducted this study because older women who are at higher risk of decreased heart function were often excluded from randomized clinical trials of trastuzumab, which is used to treat breast tumors that over-express human epidermal growth factor receptor-2 (HER-2). Past clinical trials in younger, healthier women showed improved survival, but also increased heart complications linked to trastuzumab, especially when combined with a frequently used therapy called anthracycline chemotherapy.

"We observed an even higher risk of heart failure or cardiomyopathy after trastuzumab therapy than those in past clinical trials," said lead author Dr. Jersey Chen, assistant professor of cardiology at Yale University School of Medicine and a member of the Yale Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale.

The Yale COPPER team examined the association between the use of adjuvant trastuzumab and anthracycline therapy and heart failure and cardiomyopathy, the most serious cardiotoxic complications, in 45,536 female Medicare beneficiaries with early-stage breast cancer. The use of trastuzumab has increased over time from 2.6% of the women who received any adjuvant therapy in 2000 to 22.6% in 2007.

The team found that compared with patients who received no adjuvant chemotherapy or trastuzumab; use of trastuzumab was associated with a 14% higher adjusted incidence rate for heart failure or cardiomyopathy over three years. Patients who received both trastuzumab and anthracycline had a 23.8% higher rate, and those treated with anthracycline chemotherapy alone had a 2.1% higher rate of heart failure or cardiomyopathy events over three years.

"Further study is needed to fully understand the benefits and risks of trastuzamab when they are used in the real-world population," said Cary Gross, senior author of the study and director of the COPPER Center.

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The above story is reprinted from materials provided by Yale University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jersey Chen, Jessica B. Long, Arti Hurria, Cynthia Owusu, Richard M. Steingart, Cary P. Gross. Incidence of Heart Failure or Cardiomyopathy After Adjuvant Trastuzumab Therapy for Breast Cancer. Journal of the American College of Cardiology, 2012; DOI: 10.1016/j.jacc.2012.07.068

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/godB2kMn-YU/121114162641.htm

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Fall rains bring havoc to Haiti

Jesumene St-Fleur, 48, walks with her five-year-old daughter Marie Lourdine at their home that was damaged by heavy rain brought by Hurricane Sandy in Port-au-Prince, Haiti, Monday, Nov. 12, 2012. The rain has tapered off and floodwaters no longer claw at houses, but the situation across much of Haiti remain grim, following an autumn of punishing rains that have killed scores of people and that threaten to cause even more hunger across the nation. (AP Photo/Dieu Nalio Chery)

Jesumene St-Fleur, 48, walks with her five-year-old daughter Marie Lourdine at their home that was damaged by heavy rain brought by Hurricane Sandy in Port-au-Prince, Haiti, Monday, Nov. 12, 2012. The rain has tapered off and floodwaters no longer claw at houses, but the situation across much of Haiti remain grim, following an autumn of punishing rains that have killed scores of people and that threaten to cause even more hunger across the nation. (AP Photo/Dieu Nalio Chery)

Solange Calixte 56, speaks outside her home that was damaged by heavy rain brought by Hurricane Sandy in Port-au-Prince, Haiti, Monday, Nov. 12, 2012. The rain has tapered off and floodwaters no longer claw at houses, but the situation across much of Haiti remain grim, following an autumn of punishing rains that have killed scores of people and that threaten to cause even more hunger across the nation. (AP Photo/Dieu Nalio Chery)

Homes lay in ruins after heavy rain brought by Hurricane Sandy destroyed them in Port-au-Prince, Haiti, Monday, Nov. 12, 2012. The rain has tapered off and floodwaters no longer claw at houses, but the situation across much of Haiti remain grim, following an autumn of punishing rains that have killed scores of people and that threaten to cause even more hunger across the nation. (AP Photo/Dieu Nalio Chery)

(AP) ? The rain has tapered off and floodwaters no longer claw at houses, but the situation across much of Haiti remained grim on Tuesday following an autumn of punishing rains that have killed scores of people and that threaten to cause even more hunger across the impoverished nation.

In places such as Croix-des-Missions, on the northeastern edge of the Haitian capital, the walls of dozens of homes along a pale brown river have been broken or ripped away, exposing clothes, bedding and everything else to the repeated downpours.

Heavy rains began falling in southern Haiti even before Hurricane Sandy passed just west of the country's southern peninsula the night of Oct. 24, dropping more than 20 inches of rain within a 24-hour period.

"It took away my whole home. Now I don't have anything," said Solange Calixte, a 56-year-old mother of two whose home in Croix-des-Missions was largely destroyed by floodwaters of the nearby Gray River.

One of 21,000 people the U.N. says were left homeless by Sandy, Calixte was forced to move with her belongings beneath a tarp at a neighbor's home.

And the rains have kept coming. Another front soaked much of the north late last week, causing more flooding and leaving at least a dozen dead.

So far the back-to-back storms have killed up to 66 people and the crisis is likely to worsen in coming months. Humanitarian workers anticipate a food shortage brought on by the massive flooding that destroyed yam and corn fields.

The United Nations says that as much as 90 percent of Haiti's current harvest season, much of it in the south, was lost in Sandy's floods, and the next harvest season won't begin until March. The World Food Program estimates that more than 1.5 million people are now at risk of malnutrition because they were either displaced or lost crops, forcing Haitians to rely heavily on more-expensive imports.

"This means massive inflation, hunger for a lot of people and acute malnutrition," said Johan Peleman, head of the U.N. Office for the Coordination of Humanitarian Affairs in Haiti. "Basically, the cushion is gone."

Soaring food costs have rattled Haiti before. In 2008 a jump in prices sparked more than a week of deadly rioting and ended in the ouster of the prime minister and his Cabinet.

The U.N. and Haitian government are now launching an emergency appeal to raise $39 million in hopes of stemming what they foresee as Haiti's next humanitarian crisis. This money is supposed to help 1.2 million people by providing shelter and food, repairing water, sanitation systems and schools.

Calixte, who sells clothes on the street for a living, had seen flood waters seep into her concrete house before. It sits at the edge of a wide river that cuts through the northern side of Haiti's capital. But Sandy did more. The storm led the caramel-colored river to claw away at the banks, and it ripped apart the home she had lived in since 1999.

The river has since receded and people can safely walk across through the water.

But Calixte said life is anything but normal.

"I'm at the mercy of other people," she said, her eyes tearing up.

In the north, just outside Cap-Haitien, night-long rains from a cold front caused a river to burst its bank Thursday night. The U.N. base in town was flooded, but the real damage was at the edge of ravine where floodwaters swept away cinderblock homes and the people inside them. City Hall asked aid groups for body bags.

The rains pounded the northern coast of the country through the night. The bodies of five children and a woman in her 30s were found in a village on the outskirts of Cap-Haitien and laid out in a tight row the next day.

The country's civil protection office counted 10 dead that morning, and added two more several days later. But officials such as the mayor of Cap-Haitien believe the toll could rise now that floodwaters are receding to reveal bodies trapped in thrashed homes.

"Every few hours they will call you and say, 'We found a body and need you to come collect the body,'" Jean Cherenfant said. "That's the way it has been happening the past few days: The bodies keep surfacing."

The government and foreign aid groups have responded by handing out hot meals but humanitarian workers fear it may be hard to find food down the road.

For some, the search for food is already underway.

"I'm waiting for the government to help me," Calixte said. "If they don't, I have to go out and beg for food."

______

Associated Press reporter Evens Sanon contributed reporting.

______

Trenton Daniel can be followed at http://twitter.com/trentondaniel

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-13-Haiti-Deadly%20Autumn/id-3aa6d2fb73c9420ea686333c25e01562

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